WHAT IS D-MANNOSE?
D-mannose is a monosaccharide (simple sugar) naturally produced by the body from glucose. It is also present in some fruits, such as cranberries, apples, oranges, and blueberries. It is widely used in the food, pharmaceutical, and poultry industries, acting as the source of dietary supplements and starting material for the synthesis of drugs.
In such patients, antimicrobials are often inappropriately prescribed, and their use is associated with the selection of antimicrobial-resistant organisms colonizing or infecting the urinary tract.
Recent guidelines from the main international associations, such as the American and Canadian Urological Associations, the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction, and the recent scientific literature have underlined the importance of limited antibiotic use and of new research on molecules that interact with bacterial load or virulence mechanisms of uropathogens for the treatment of UTI.
Among these molecules, several studies have identified D-mannose, which is characterized by a non-pharmacological, non-metabolic, non-bacteriostatic, or bactericidal, but biomechanical mechanism of action and does not affect antibiotic resistance.
MANNOSE ROLE IN ELIMINATING THE UROPATHOGENIC E. COLI (UPEC)
Its peculiarity is that despite it being a simple molecule, this sugar is not metabolized by the organism. Consequently, it is not stored in the liver or other organs, but it is excreted unconverted into the urine via the kidneys. About 60 min after ingestion, it arrives unchanged in the urinary tract. (Parazzini et al., 2022)
The most common agent of UTI/cystitis is the uropathogenic E. coli (UPEC). Several studies have shown that, in the urine, E. Coli attaches to D-mannose. This mechanism is based on the structural similarity between D-mannose and urothelial mannosylated receptors exposed by the epithelium of the urinary tract. Binding free D-mannose, bacteria are blocked in the urine and then eliminated by the urinary tract.
REFERENCES:
Parazzini, F., Ricci, E., Fedele, F., Chiaffarino, F., Esposito, G., & Cipriani, S. (2022, June 15). Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/ cystitis (Review). Biomedical Reports
Purewellness D-MANNOSE
Our D-Mannose powder is responsibly sourced, certified kosher, vegan, and non genetically modified. We suggest 1g (1000mg) x2 daily, or a single dose of 2g (2000 mg).Take it with water or natural (unsweetened) high-D-Mannose fruit juice, such as cranberry, blueberry, and apple juice.
Other products that support a healthy urinary tract include:
1: Purewellness Ascorbic Acid Powder (Vitamin C), as it increases the acidity of urine, killing off the bacteria that causes infection;
2: Purewellness Probiotics- Gut Care Powder, as it promotes a healthy balance of bacteria in our gut.
Purewellness provides an exclusive selection of fruit extract powders, superfood powders, probiotics, and fibers.
If you need assistance understanding the difference and role of our supplements, feel free to contact our nutrition and naturopathy experts.
We are looking forward to helping you on a journey for better health!
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